---Product Description---
We know that vitamins are important for the body. People's bones, heart health, brain and nervous system health are inseparable from vitamins. Although most people are already familiar with vitamins A, B, C, D, and E, there is a "forgotten vitamin" that needs to be introduced in detail, and that is vitamin K. Vitamin K2 is a fat-soluble vitamin and one of the important vitamins that the human body cannot lack.
Vitamin K2 is produced by vitamin K1 in the bacteria or other tissues in our intestines. There are several types of vitamin K2 with more or less carbon atoms on the side chain of its chemical structure. According to the number of carbon atoms, it is also called MK-4, MK-7, etc. Studies have shown that the half-life of vitamin K1 is relatively short, and it will be cleared by the liver within 8 hours. In contrast, the half-life of vitamin K2 is relatively long, up to 72 hours, which means that it can maintain longer biological activity in the human body. Compared with vitamin K1 and vitamin K2 (MK4), vitamin K2 (MK7) shows higher bioavailability and efficacy
--Basic information of Vitamin K2 (MK7)
Name: Vitamin K2 (MENAQUINONE-7)
CAS: 2124-57-4
Molecular formula: C46H64O2
Molecular weight: 649.00
The role and function of vitamin K2 (MK7)
1. Anti-osteoporosis
① Promote bone mineralization: Osteocalcin can promote calcium salt deposition, increase the rate of bone mineralization, maintain normal bone calcification and crystal formation and cartilage mineralization rate, and directly reflect bone formation and bone reconstruction
② Promote bone formation: Vitamin K2mk7 Menaquinone 7 is a regulator of bone-specific gene transcription, enhancing the accumulation of collagen and improving bone quality
③Inhibit bone resorption: It can slow down the dissolution of bone calcium and the dissolution of bone matrix by tissue proteases through the creation of an acidic environment by osteoclasts
2. Anti-arterial calcification and osteoarthritis
Vitamin K2mk7 Menaquinone 7 has a strong inhibitory effect on cartilage and vascular calcification, and can effectively remove abnormal calcium plaques.
3. Anti-tumor
Vitamin K2mk7 Menaquinone 7 can inhibit tumor growth by negatively regulating the activity of tyrosine kinase and phosphatase related to cell carcinogenesis, as well as regulating regulatory factors related to cell proliferation, ultimately leading to the cell cycle of tumor cells.
4. Delaying aging
Vitamin K2mk7 Menaquinone 7 has stronger antioxidant activity than vitamin E and coenzyme Q10, and has significant skin beautification and anti-aging effects
5. Improve dental health.
One of the main regulators of dental health is osteocalcin, a protein essential for bone metabolism that can be activated by Vitamin K2mk7 Menaquinone 7. Dentin is the calcified tissue beneath the enamel on teeth, and osteocalcin can trigger mechanisms that stimulate the growth of new dentin.
6. Improve diabetes.
Vitamin K2mk7 Menaquinone 7 can upregulate insulin genes, promote pancreatic beta cells, release insulin, improve the body's metabolic level, and help the recovery of diabetic patients.
Unquestionable safety
★ In 2006, the U.S. FDA approved the use of vitamin K2 as a food and fortified food additive, which marked the approval of Vitamin K2mk7 Menaquinone 7 by the world's most authoritative food and drug regulatory agency, and its safety is unquestionable.
★ In 2007, the European Union approved Vitamin K2mk7 Menaquinone 7 to be added as a food fortifier in all member states, which means that the world's most powerful food and drug research and management agency has a new understanding of the importance of vitamin K2.
★ As early as 2001, Japan approved the sale of Vitamin K2mk7 Menaquinone 7 as a drug for the treatment of osteoporosis. Why did it take 6 years for Europe and the United States to approve it? This reflects the rigor of food and drug research. After all, human life is at stake, and safety comes first. China also approved Vitamin K2mk7 Menaquinone 7 for sale after 8 years of research.
Vitamin K2mk7 Menaquinone 7 is mostly found in fermented foods, such as natto, sauerkraut and some cheeses, but these foods are generally lacking in the daily diet of Chinese people. To maintain bone health and prevent osteoporosis, healthy adults need to supplement about 50-120 micrograms of vitamin K2 per day, while people with osteoporosis and bone sub-health need to increase the amount appropriately.
Biosynthetic pathway (microbial production of Vitamin K2mk7 Menaquinone 7)
(1) Vitamin K2mk7 Menaquinone 7 is generally produced using cooked soybeans as a culture medium using microorganisms such as Bacillus subtilis and Bacillus natto
(2) Vitamin K2mk7 Menaquinone 7 (Natto extraction)
Add 2 volumes of 95% ethanol to natto, stir and extract for 30 minutes, filter out the extract, centrifuge at 4, 6000r/min for 30 minutes, collect the supernatant, Vitamin K2 (35) is contained in the ethanol extract, remove the ethanol after vacuum concentration, add an equal volume of n-butanol to the extract, vigorously shake and extract Vitamin K2 (35) into the n-butanol phase, stand still and separate, absorb the organic phase, at this time Vitamin K2 (35) is dissolved in the phase, then, concentrate in a rotary evaporator under the condition of N2 gas, freeze-dry to obtain Vitamin K2mk7 Menaquinone. 7
Storage conditions:
Vitamin K2mk7 Menaquinone 7 Oil: sealed, protected from light; stored in a cool and dry place with nitrogen or vacuum, the best storage temperature of the product is below 20℃.
Vitamin K2mk7 Menaquinone 7 Powder: sealed, protected from light; stored in a cool and dry place, the best storage temperature of the product is below 20℃.
Vitamin K2mk7 Menaquinone 7 (MK7 comes from menaquinone 7). Long-chain MK-7 has a longer half-life, so the level in the blood is more stable, has the highest bioavailability, is more easily absorbed, and remains active longer. The most potent form of Vit K2.
The main function of Vitamin K2mk7 Menaquinone 7 for bone health is to transport calcium ions (Ca2+) in the blood to the bones for bone formation. At the same time, more calcium in the bone matrix means that it can be used in soft tissues. Harmful calcium deposits are reduced. Recent studies have shown that the general population's dietary intake of Vitamin K2mk7 Menaquinone 7 is inadequate and that supplementation with Vitamin K2mk7 Menaquinone 7 may improve bone health and reduce health care costs associated with osteoporosis.
Vitamin K2mk7 Menaquinone 7 has a unique compound regulatory effect of promoting bone formation and mineralization and inhibiting bone resorption. It has a significant synergistic effect when used in combination with clinical first-line drugs for the treatment of osteoporosis.
---Specifications Data Sheet---
